We await further data from this ongoing study to assess other potential risk factors and to confirm the strength of association in a larger sample size. Small head size became evident progressively on prenatal imaging, and the head circumference microcefalia. Possivel associacao entre a infeccao pelo virus zika e a. Nervous system diseases embryonic, fetal and postnatal resulting from zikv infection. This imaging series demonstrates delayed but progressive cerebral development. Pdf microcephaly in infants, pernambuco state, brazil, 2015. Zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. Springdale health department zika virus prevention june 2016. The original isolation of the zika virus zikv, a flavivirus member of the flaviviridae family, was obtained in 1947 from the blood of a febrile rhesus monkey exposed at the zika forest near lake victoria, in the outskirts of entebbe, the capital of uganda. However, microcephaly peaked in october and demonstrated central nervous system abnormalities with brain dysgenesis and intracranial calcifications consistent with an intrauterine infection. A doenca e congenital ou adquirida mas nao pode ser curada. The association between microcephaly and congenital zika virus infection was confirmed. Nunes ml, carlini cr, marinowic d, neto fk, fiori hh, scotta mc, et al.
Association between microcephaly, zika virus infection. Time lags between exanthematous illness attributed to zika. Microcephaly is a fetal condition diagnosed in pregnancy or at birth and is linked to a variety of genetic causes, maternal behaviors and a number of infections contracted by the pregnant mother which pass to the fetus. Mas a cabeca pequena e apenas a consequencia mais visivel. Cdc has developed interim guidelines for health care providers in the united states caring for pregnant women during a zika virus outbreak. The data were extracted retrospectively from the medical files at the sector of the. Aps o nascimento, 50% do crescimento completase aos 12 meses.
Travelers who go to places with outbreaks of zika can be infected with zika, and zika infection during pregnancy can cause microcephaly and other severe fetal brain defects including severe vision problems. A microcefalia geralmente resulta do desenvolvimento anormal do cerebro. Muchos ninos con microcefalia pueden no presentar otros sintomas al nacer, pero. Download free fisiopatologia microcefalia pdf backupfarm. Microcefalia transtorno congenito gravidez avaliacao. Association between zika virus infection and microcephaly. We provide evidence of the absence of an effect of other potential factors, such as exposure to pyriproxyfen or vaccines tetanus, diphtheria, and acellular pertussis, measles and rubella, or measles, mumps, and rubella during pregnancy, confirming the findings of an ecological study. Exposicion fetal a alcohol oct 2010 pediatriausach.
The incidence of microcephaly can vary wildly because of the complex medical, social and economic factors involved. Testing is ongoing to exclude known infectious causes. Our data suggest that the microcephaly epidemic is a result of congenital zika virus infection. Lesao do snc, microcefalia, retardo mental fissura labial e palatina atresia intestinal defeitos no septo atrial e ventricular defeitos dos membros, polidactilia retardo no crescimento prenatal polidactilia alcool etanol sindrome do alcoolismo fetal retardo do crescimento intrauterino retardo mental. Altered intrauterine ultrasound, fetal head circumference growth and. Microcephaly in infants, pernambuco state, brazil, 2015. A transmissao materno fetal do virus zika durante a gestacao ja foi confirmada 4,7,8. Pode ser provocada pela exposicao a substancias nocivas durante o desenvolvimento fetal ou estar associada com problemas ou sindromes geneticas hereditarias. These guidelines include recommendations for pregnant women considering travel to an area with zika virus transmission and recommendations for screening, testing, and management of pregnant returning travelers. The congenital syndrome associated with zikv is consistent with the rare fetal brain disruption sequence, with only 20 reported cases in the world before 2001 10, 11.
Microcephaly is a birth defect where a babys head is smaller than expected when compared to babies of the same sex and age. Oct 11, 2012 microcefalia asociada a las craneosinostosis. Microcephaly is a condition in which the size of the head is smaller than normal because the brain. Infeccao pelo virus zika e infeccao fetal microcefalia associada ao virus zika david m. Infeccao do virus zika em gestantes e microcefalia. Morens, md, office of the director, national institute of allergy and infectious diseases, national institutes of health, bethesda, md anthony s. Babies may also have microcephaly if the mother used alcohol or drugs during pregnancy. Zika virus infection in pregnant women and microcephaly scielo. Association between microcephaly, zika virus infection, and. It can be present at birth or may develop in the first few years of life. As alteraes podem ocorrer antes ou aps o nascimento. Until 2007, the literature documents that the number of people affected by this virus did not exceed 50.
Pregnant women should not travel to any area with a zika virus outbreak. Trends of microcephaly and severe arthrogryposis in three. We provide evidence of the absence of an effect of other potential factors, such as exposure to pyriproxyfen or vaccines tetanus, diphtheria, and acellular pertussis, measles and rubella, or measles, mumps, and rubella during pregnancy, confirming the findings of an ecological study of pyriproxyfen in. Vision problems can include macular and optic nerve damage. Microcephaly is a condition in which the size of the head is smaller than normal because the brain has not developed properly or has stopped growing. No todas las craneosinostosis presentan microcefalia.
47 342 1227 789 857 1468 1501 1286 964 1295 559 1407 344 1192 1409 619 405 32 287 1257 54 1492 472 1464 1200 1266 1158 1459 719 1001 1412